Granuloma annulare (GA) is a benign inflammatory dermatosis. T. Colcott Fox first described granuloma annulare in ; however, not until. Granuloma annulare. Authoritative facts about the skin from DermNet New Zealand. Granuloma annulare often causes a slightly raised patch on your skin that has a noticeable (and sometimes scaly) border.

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In most cases of granuloma annulare, no treatment is required because the patches disappear by themselves in a few months, leaving no trace.

Granuloma annulare – Symptoms and causes – Mayo Clinic

Despite the dramatic appearance of this cutaneous eruption, it generally is asymptomatic; however, there may be some mild pruritus. Lack of an association between granuloma annulare and type 2 diabetes mellitus.

Granuloma annulare may cause no symptoms, but affected areas are often tender when knocked. The two skin conditions look similar. Clearly, well-designed clinical trials are needed granloma better direct treatment. Some studies, however, have found that people with certain diseases, anuular as an HIV infection, may be more likely to develop granuloma annulare.

Granuloma annulare associated with prostate carcinoma. None of these can be relied upon to clear it, and there are some potential adverse effects. Acanthosis nigricans Confluent and reticulated papillomatosis Callus Ichthyosis acquisita Arsenical keratosis Chronic scar granjloma Hyperkeratosis lenticularis perstans Hydrocarbon keratosis Hyperkeratosis of the nipple and areola Inverted follicular keratosis Lichenoid keratosis Multiple minute digitate hyperkeratosis PUVA keratosis Reactional keratosis Stucco keratosis Thermal keratosis Viral keratosis Warty dyskeratoma Waxy keratosis of childhood other hypertrophy: Barron DF, et anilar.


This skin condition tends to clear on its own without treatment. Treatments for chronic forms of the disorder include corticosteroid drugs such as dapsone and isotretinoin, which is the synthetic form of retinoic acid related to vitamin A. Mosby Elsevier, Spain, Potassium iodide in the treatment of disseminated granuloma annulare.

Patients with diabetes mellitus had a higher incidence of chronic relapsing granuloma annulare than patients without diabetes.

Diagnosis and Management of Granuloma Annulare

Mechanisms of Clinical Signs. Generalised granuloma annulare successfully treated with PUVA. They’re often found in skin folds in the armpits and groin.

The patches may be red, reddish brown, or violet.

Granuloma annulare affects the skin of children, teenagers or young adults or older adults, less commonly. Because localized granuloma annulare is self-limited and asymptomatic, treatment usually is not necessary. Granuloma annulare is occasionally associated with diabetes or thyroid disease, most often when lesions are numerous or widespread. These doctors are the skin experts who can help you get an accurate diagnosis.

In most cases, the sizes of the lesions range from one to five centimeters. No benefit over placebo. In this series of eight patients, there was no advantage of high-dose potassium iodide over placebo. The rash is sometimes made up of small raised spots that form symmetrical rings 10cm 4 inches or more across.

Some forms of GA tend to run in families familialbut the exact mode of inheritance has not yet been determined. The lesions may be solitary or in clusters. Have injured your skin recently Feel any pain or itch Take any medications Have been diagnosed with a disease The skin exam and information you provide are often enough to diagnose granuloma annulare. Granuloma annulare is more common in children and young adults, although it can affect people of all ages.


You may have a single mass or clusters of lumps. The most commonly affected sites include the feet, hands, and fingers.

Most medical literature on treatment of granuloma annulare is limited to individual case reports and small series of patients treated without a control group. The incidence of side effects is very low. Biopsy shows palisading granuloma with transepithelial elimination of degenerating collagen fibers. Localised granuloma annulare is sometimes associated with autoimmune thyroiditis but it does not clear up with thyroid replacement.

Rare Disease Database

Setterfield J, et al. Not everyone who has one of these diseases will develop granuloma annulare. Disseminated granuloma annulare—treatment with fumaric acid esters. Although uncommon, cases of granuloma annulare occurring in siblings, twins, and successive generations have been reported.

They have been presumed effective because of their immunosuppressive and anti-inflammatory properties. It is also more common in women. Treatment is not always successful. Earn up to 6 CME credits per issue. Disseminated granuloma annulare in a year-old woman on her A inner thigh and B elbows.

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